UBR3 Antibody, HRP conjugated

Datasheet
Code CSB-PA757959LB01HU
Size US$299
Uniprot No. Q6ZT12
Protocols ELISA Protocol
Immunogen Recombinant Human E3 ubiquitin-protein ligase UBR3 protein (960-1113AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650), UBR3, KIAA2024 ZNF650
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names UBR3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families UBR1 family
Database Links

HGNC: 30467

OMIM: 613831

KEGG: hsa:130507

STRING: 9606.ENSP00000396068

UniGene: Hs.379548

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