UFC1 Antibody, HRP conjugated

Code CSB-PA897483LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UFC1 Polyclonal antibody
Uniprot No.
Target Names
UFC1
Alternative Names
CGI-126 antibody; HSPC155 antibody; Ubiquitin fold modifier conjugating enzyme 1 antibody; Ubiquitin-fold modifier-conjugating enzyme 1 antibody; UFC1 antibody; UFC1_HUMAN antibody; Ufm1 conjugating enzyme 1 antibody; Ufm1-conjugating enzyme 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin-fold modifier-conjugating enzyme 1 protein (1-167AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
Gene References into Functions
  1. that UFC1 regulates survival of Osteoarthritis chondrocytes through physically association with miR-34a PMID: 27529373
  2. Autoantibodies binding to Ufc1 were found in 19 of 29 patients (66%) with active mycobacterial infections. PMID: 25213431
  3. Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 to Ufc1, and Uba5 381-404 was identified to be the minimal region for Ufc1 recognition PMID: 25084390
  4. UFC1 interact with the mRNA stabilizing protein HuR to increase levels of beta-catenin in hepatocellular carcinoma. PMID: 25449213
  5. NCAM140 interacts with ufc1 and its trafficking and endocytosis is upregulated in the presense of Ufm1. PMID: 24726913
  6. The structure of human Ufc1 was solved by using both NMR spectroscopy and X-ray crystallography PMID: 19101823
  7. Identification of a novel enzyme called UFC1 for Ufm1-conjugating enzyme 1. PMID: 15071506

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Protein Families
Ubiquitin-conjugating enzyme family, UFC1 subfamily
Database Links

HGNC: 26941

OMIM: 610554

KEGG: hsa:51506

STRING: 9606.ENSP00000356982

UniGene: Hs.301412

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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