UGT8 Antibody

1. An increase in the immunolabelling of ceramide was observed in cells where UDP glycosyltransferase 8 (UGT8) was down-regulated as opposed to cells where UGT8 was either not regulated or was up-regulated. PMID: 28746357
2. Data indicate that ceramide galactosyltransferase (UGT8), although enhanced in non-small cell lung carcinoma (NSCLC) tissues, does not meet the criteria of a lung tumor marker. PMID: 27620310
3. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. PMID: 24821492
4. A new role was identified for UGT8 as a modulator of bile acid homeostasis. PMID: 25519837
5. High expression of UGT8 accompanied by accumulation of GalCer in MDA-MB-231 cells is associated with a much higher proliferative index and a lower number of apoptotic cells in comparison to the MDA/LUC-shUGT8 cells. PMID: 24391908
6. Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. PMID: 23118445
7. UGT8 is a significant index of tumour aggressiveness and is seen in lung metastases of breast cancer. PMID: 20648017
8. Single-nucleotide polymorphisms (SNPs) were found in UGT8 gene PMID: 12376738
9. the GC-box and CRE function cooperatively, and that the CRE regulates the cell-specific expression of the hCGT gene PMID: 15229398
10. We postulate that molecular link between defective GALT enzyme, which result in classic galactosemia and the cerebroside galactosyl transferase, responsible for galactosylation of cerebrosides, is dependent on concentrations of UDP-galactose. PMID: 16125333
11. Gene expression of galactosyl ceramide synthase associated with poor pathohistological grading in breast cancer PMID: 19125296

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HGNC: 12555

OMIM: 601291

KEGG: hsa:7368

STRING: 9606.ENSP00000311648

UniGene: Hs.144197