UQCRQ Antibody

Code CSB-PA03855A0Rb
Size US$166
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  • Western blot
    All lanes: UQCRQ antibody at 2µg/ml
    Lane 1: EC109 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 10 kDa
    Observed band size: 30 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UQCRQ Polyclonal antibody
Uniprot No.
Target Names
UQCRQ
Alternative Names
Complex III subunit 8 antibody; Complex III subunit VIII antibody; Cytochrome b-c1 complex subunit 8 antibody; QCR8 antibody; QCR8_HUMAN antibody; QP-C antibody; QPC antibody; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein antibody; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C antibody; Uqcrq antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytochrome b-c1 complex subunit 8 protein (2-78AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The UQCRQ Antibody (Product code: CSB-PA03855A0Rb) is Non-conjugated. For UQCRQ Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA03855B0Rb UQCRQ Antibody, HRP conjugated ELISA
FITC CSB-PA03855C0Rb UQCRQ Antibody, FITC conjugated
Biotin CSB-PA03855D0Rb UQCRQ Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Gene References into Functions
  1. QP-C protein gene expression involved in the development of hyperpigmentation. PMID: 25950827
  2. Decreased electron Transport Complex III activity is associated with ulcerative colitis. PMID: 20440543
  3. We thus suggest that a homozygous mutation in UQCRQ is associated with defective function of mitochondrial complex III, leading to a severe autosomal-recessive neurological phenotype. PMID: 18439546
Involvement in disease
Mitochondrial complex III deficiency, nuclear 4 (MC3DN4)
Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein.
Protein Families
UQCRQ/QCR8 family
Database Links

HGNC: 29594

OMIM: 612080

KEGG: hsa:27089

STRING: 9606.ENSP00000367934

UniGene: Hs.146602

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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