Name: USP20 Antibody
Brand: CUSABIO
SKU: CSB-PA025711GA01HU

Product Details

Uniprot No.	Q9Y2K6
Target Names	USP20
Alternative Names	Deubiquitinating enzyme 20 antibody; hVDU2 antibody; KIAA1003 antibody; LSFR 3A antibody; LSFR3A antibody; pVHL interacting deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 20 antibody; Ubiquitin carboxyl-terminal hydrolase 20 antibody; ubiquitin specific peptidase 20 antibody; Ubiquitin specific processing protease 20 antibody; Ubiquitin specific protease 20 antibody; Ubiquitin thioesterase 20 antibody; Ubiquitin thiolesterase 20 antibody; Ubiquitin-specific-processing protease 20 antibody; UBP20_HUMAN antibody; USP 20 antibody; USP20 antibody; VDU 2 antibody; VDU2 antibody; VHL interacting deubiquitinating enzyme 2 antibody; VHL-interacting deubiquitinating enzyme 2 antibody
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Immunogen	Human USP20
Immunogen Species	Homo sapiens (Human)
Isotype	IgG
Purification Method	Antigen Affinity purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications	ELISA,WB,IHC
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function	Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene References into Functions	USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions. PMID: 28167606 we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2. PMID: 25708858 findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis PMID: 25666616 data establish a new function of USP20 in genome maintenance and DNA repair. PMID: 24923443 Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID: 22552337 Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling. PMID: 21525354 identification and description of VDU2 in human cells PMID: 12865408 von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha. PMID: 15776016 USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface. PMID: 19424180 Show More Hide All
Subcellular Location	Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Protein Families	Peptidase C19 family, USP20/USP33 subfamily
Database Links	HGNC: 12619 OMIM: 615143 KEGG: hsa:10868 STRING: 9606.ENSP00000313811 UniGene: Hs.5452

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USP20 Antibody

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Code	CSB-PA025711GA01HU
Size	US$685
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