USP3 Antibody

1. Data found that USP3 was overexpressed in gastric cancer (GC) tissues and cells. USP3 overexpression can be a useful biomarker for predicting the outcomes of GC patients. Moreover, USP3 was shown to influence cell proliferation by regulating cell cycle control and metastasis-related proteins. In vivo experiments showed that USP3 promoted GC tumor growth and metastasis. PMID: 30168892
2. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. PMID: 28807825
3. Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8-mediated ubiquitination. PMID: 24196443
4. the role of UCP3 gene in functional status and survival at old age. PMID: 22743239
5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20445134
6. Ubiquitin-specific protease 3 (USP3) is a deubiquitinating enzyme for monoubiquitinated histones H2A and H2B; USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. PMID: 17980597

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HGNC: 12626

OMIM: 604728

KEGG: hsa:9960

STRING: 9606.ENSP00000369681

UniGene: Hs.458499