USP3

USP3, ubiquitin-specific protease 3, alias Ubiquitin-specific protease 3, KIAA0146 and others. It is a deubiquitinating enzyme, an important member of the deubiquitinating enzyme family, and functions mainly in the nucleus.The mechanism of action of USP3 is to specifically cleave ubiquitin chains on proteins through its catalytic structural domains, thus preventing these proteins from being degraded by the proteasome, and maintaining the functionality and stability of the proteins.USP3 activity participates in various cellular processes such as the DNA damage response, cell cycle regulation, and epithelial-mesenchymal transition. mesenchymal transition, and many other cellular processes.

USP3 has a wide range of biological significance, and it is involved in the regulation of a variety of signaling pathways, including cell proliferation, migration, apoptosis, and stemness maintenance of tumor cells.Aberrant function of USP3 has been associated with the development of a variety of diseases, and in particular, in the field of cancer, the overexpression of USP3 has been associated with the invasiveness, metastasis, and poor prognosis of a variety of tumors. For example, USP3 can stabilize certain tumor-promoting factors through deubiquitination and activate signaling pathways such as PI3K/AKT and NF-κB, which in turn promote tumor cell survival and proliferation. In addition, USP3 plays an important role in the activation of inflammatory vesicles, cell metabolism, and stem cell self-renewal. Thus, USP3 not only plays a key role in cell physiological processes, but also is a potential target for disease treatment.