USP36 Antibody, Biotin conjugated

Code CSB-PA878959LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) USP36 Polyclonal antibody
Uniprot No.
Target Names
USP36
Alternative Names
Deubiquitinating enzyme 1 antibody; Deubiquitinating enzyme 36 antibody; DUB1 antibody; FLJ12851 antibody; KIAA1453 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; Ubiquitin specific peptidase 36 antibody; Ubiquitin specific processing protease 36 antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin thiolesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody; UBP36_HUMAN antibody; Usp36 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 protein (670-881AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
Gene References into Functions
  1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
  2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
  3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
  4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
  5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
  6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
  7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
  8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
  9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
  10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
  11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
  12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

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Subcellular Location
Nucleus, nucleolus. Cytoplasm.
Protein Families
Peptidase C19 family
Tissue Specificity
Broadly expressed.
Database Links

HGNC: 20062

OMIM: 612543

STRING: 9606.ENSP00000310590

UniGene: Hs.464243

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