USP46 Antibody, HRP conjugated

Code CSB-PA025738LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) USP46 Polyclonal antibody
Uniprot No.
Target Names
USP46
Alternative Names
Deubiquitinating enzyme 46 antibody; FLJ11850 antibody; FLJ12552 antibody; FLJ14283 antibody; FLJ39393 antibody; Ubiquitin carboxyl terminal hydrolase 46 antibody; Ubiquitin carboxyl-terminal hydrolase 46 antibody; Ubiquitin specific peptidase 46 antibody; Ubiquitin specific processing protease 46 antibody; Ubiquitin specific protease 46 antibody; Ubiquitin thioesterase 46 antibody; Ubiquitin thiolesterase 46 antibody; Ubiquitin-specific-processing protease 46 antibody; UBP46_HUMAN antibody; USP46 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 46 protein (66-166AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Gene References into Functions
  1. Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation. PMID: 25855980
  2. USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt. PMID: 22391563
  3. results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population. PMID: 21663972
  4. These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46. PMID: 20111060
Protein Families
Peptidase C19 family, USP12/USP46 subfamily
Tissue Specificity
Broadly expressed.
Database Links

HGNC: 20075

OMIM: 612849

KEGG: hsa:64854

STRING: 9606.ENSP00000407818

UniGene: Hs.7966

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