USP46 Antibody

Code CSB-PA025738GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
USP46
Alternative Names
Deubiquitinating enzyme 46 antibody; FLJ11850 antibody; FLJ12552 antibody; FLJ14283 antibody; FLJ39393 antibody; Ubiquitin carboxyl terminal hydrolase 46 antibody; Ubiquitin carboxyl-terminal hydrolase 46 antibody; Ubiquitin specific peptidase 46 antibody; Ubiquitin specific processing protease 46 antibody; Ubiquitin specific protease 46 antibody; Ubiquitin thioesterase 46 antibody; Ubiquitin thiolesterase 46 antibody; Ubiquitin-specific-processing protease 46 antibody; UBP46_HUMAN antibody; USP46 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human USP46
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Gene References into Functions
  1. Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation. PMID: 25855980
  2. USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt. PMID: 22391563
  3. results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population. PMID: 21663972
  4. These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46. PMID: 20111060
Protein Families
Peptidase C19 family, USP12/USP46 subfamily
Tissue Specificity
Broadly expressed.
Database Links

HGNC: 20075

OMIM: 612849

KEGG: hsa:64854

STRING: 9606.ENSP00000407818

UniGene: Hs.7966

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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