USP46 Antibody

Datasheet

Code	CSB-PA025738LA01HU
Size	US$166
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Image	Immunofluorescence staining of A549 cells with CSB-PA025738LA01HU at 1:267, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) USP46 Polyclonal antibody

Uniprot No.

P62068

Target Names

USP46

Alternative Names

Deubiquitinating enzyme 46 antibody; FLJ11850 antibody; FLJ12552 antibody; FLJ14283 antibody; FLJ39393 antibody; Ubiquitin carboxyl terminal hydrolase 46 antibody; Ubiquitin carboxyl-terminal hydrolase 46 antibody; Ubiquitin specific peptidase 46 antibody; Ubiquitin specific processing protease 46 antibody; Ubiquitin specific protease 46 antibody; Ubiquitin thioesterase 46 antibody; Ubiquitin thiolesterase 46 antibody; Ubiquitin-specific-processing protease 46 antibody; UBP46_HUMAN antibody; USP46 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 46 protein (66-166AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The USP46 Antibody (Product code: CSB-PA025738LA01HU) is Non-conjugated. For USP46 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA025738LB01HU	USP46 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025738LC01HU	USP46 Antibody, FITC conjugated
Biotin	CSB-PA025738LD01HU	USP46 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:200-1:500

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

Gene References into Functions

Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation. PMID: 25855980
USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt. PMID: 22391563
results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population. PMID: 21663972
These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46. PMID: 20111060

Protein Families

Peptidase C19 family, USP12/USP46 subfamily

Tissue Specificity

Broadly expressed.

Database Links

HGNC: 20075

OMIM: 612849

KEGG: hsa:64854

STRING: 9606.ENSP00000407818

UniGene: Hs.7966

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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