USP48 Antibody

1. USP48 inactivation reduces chromosomal instability of Fanconi anemia (FA)-defective cells. Our results highlight a role for USP48 in controlling DNA repair and suggest it as a potential target that could be therapeutically exploited for FA. PMID: 29891926
2. In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels. PMID: 28233861
3. down-regulation of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stability PMID: 28874458
4. study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis. PMID: 28623188
5. Data suggest that ubiquitin specific protease-48 (USP48) promotes genome stability by antagonizing BRCA1 E3 ligase function. PMID: 29335415
6. this study demonstrates that USP48 controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB/RelA in the nucleus. PMID: 25486460
7. Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung. PMID: 15354349
8. The Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta-mediated NF-kappaB activation, but did not inhibit Smad-mediated transcription activation. PMID: 16214042
9. data demonstrate a crucial role for the dynamic interaction between D3R and USP48 in the regulation of NHE3 expression and function PMID: 24308971

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HGNC: 18533

OMIM: 617445

KEGG: hsa:84196

STRING: 9606.ENSP00000309262

UniGene: Hs.467524