USP48 Antibody, HRP conjugated

Code CSB-PA774808LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) USP48 Polyclonal antibody
Uniprot No.
Target Names
USP48
Alternative Names
AAH67261 antibody; Deubiquitinating enzyme 48 antibody; DKFZp762M1713 antibody; EC 3.1.2.15 antibody; Kiaa4202 antibody; MGC132556 antibody; MGC14879 antibody; RAP1GA1 antibody; Synaptic ubiquitin specific protease antibody; synUSP antibody; Ubiquitin carboxyl terminal hydrolase 48 antibody; Ubiquitin carboxyl-terminal hydrolase 48 antibody; Ubiquitin specific peptidase 48 antibody; Ubiquitin specific processing protease 48 antibody; Ubiquitin specific protease 31 antibody; Ubiquitin specific protease 48 antibody; Ubiquitin thioesterase 48 antibody; Ubiquitin thiolesterase 48 antibody; Ubiquitin-specific-processing protease 48 antibody; UBP48_HUMAN antibody; USP31 antibody; USP48 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 48 protein (358-508AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.
Gene References into Functions
  1. USP48 inactivation reduces chromosomal instability of Fanconi anemia (FA)-defective cells. Our results highlight a role for USP48 in controlling DNA repair and suggest it as a potential target that could be therapeutically exploited for FA. PMID: 29891926
  2. In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels. PMID: 28233861
  3. down-regulation of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stability PMID: 28874458
  4. study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis. PMID: 28623188
  5. Data suggest that ubiquitin specific protease-48 (USP48) promotes genome stability by antagonizing BRCA1 E3 ligase function. PMID: 29335415
  6. this study demonstrates that USP48 controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB/RelA in the nucleus. PMID: 25486460
  7. Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung. PMID: 15354349
  8. The Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta-mediated NF-kappaB activation, but did not inhibit Smad-mediated transcription activation. PMID: 16214042
  9. data demonstrate a crucial role for the dynamic interaction between D3R and USP48 in the regulation of NHE3 expression and function PMID: 24308971

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Peptidase C19 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 18533

OMIM: 617445

KEGG: hsa:84196

STRING: 9606.ENSP00000309262

UniGene: Hs.467524

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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