VPREB3 Antibody, Biotin conjugated

Code CSB-PA891724LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VPREB3 Polyclonal antibody
Uniprot No.
Target Names
VPREB3
Alternative Names
N27C7 2 antibody; N27C7-2 antibody; Pre B lymphocyte protein 3 antibody; Pre-B lymphocyte protein 3 antibody; PRO619 antibody; Protein VPreB3 antibody; UNQ355 antibody; VPRE3_HUMAN antibody; VPREB3 antibody; VpreB3 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pre-B lymphocyte protein 3 protein (21-122AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Gene References into Functions
  1. A possible role for VPREB3 in aldosterone biosynthesis. PMID: 25861052
  2. levels of VPREB3 mRNA in aldosterone-producing adenomas directly correlate to plasma aldosterone concentrations in peripheral blood of respective patients PMID: 25861052
  3. mouse VpreB3 associates with mu heavy chains early in pre-B cell receptor biosynthesis PMID: 8491176
  4. VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in chicken B cells PMID: 14670953
  5. the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas. PMID: 24493312
  6. Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles. PMID: 20823132
  7. the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation. PMID: 15757909

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Protein Families
Immunoglobulin superfamily
Tissue Specificity
Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
Database Links

HGNC: 12710

OMIM: 605017

KEGG: hsa:29802

STRING: 9606.ENSP00000248948

UniGene: Hs.136713

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