VPREB3 Antibody

Code CSB-PA025888GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
VPREB3
Alternative Names
N27C7 2 antibody; N27C7-2 antibody; Pre B lymphocyte protein 3 antibody; Pre-B lymphocyte protein 3 antibody; PRO619 antibody; Protein VPreB3 antibody; UNQ355 antibody; VPRE3_HUMAN antibody; VPREB3 antibody; VpreB3 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human VPREB3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Gene References into Functions
  1. A possible role for VPREB3 in aldosterone biosynthesis. PMID: 25861052
  2. levels of VPREB3 mRNA in aldosterone-producing adenomas directly correlate to plasma aldosterone concentrations in peripheral blood of respective patients PMID: 25861052
  3. mouse VpreB3 associates with mu heavy chains early in pre-B cell receptor biosynthesis PMID: 8491176
  4. VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in chicken B cells PMID: 14670953
  5. the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas. PMID: 24493312
  6. Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles. PMID: 20823132
  7. the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation. PMID: 15757909

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Protein Families
Immunoglobulin superfamily
Tissue Specificity
Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
Database Links

HGNC: 12710

OMIM: 605017

KEGG: hsa:29802

STRING: 9606.ENSP00000248948

UniGene: Hs.136713

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