VPS26A Antibody, HRP conjugated

Code CSB-PA025898LB11HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) VPS26A Polyclonal antibody
Uniprot No. O75436
Target Names VPS26A
Alternative Names
FLJ12930 antibody; HB 58 antibody; HB58 antibody; Hbeta 58 antibody; Hbeta 58 homolog antibody; Hbeta58 antibody; Hbeta58 homolog antibody; hVPS 26 antibody; hVPS26 antibody; MGC94168 antibody; PEP 8A antibody; PEP8A antibody; Vacuolar protein sorting 26 A antibody; Vacuolar protein sorting 26 antibody; Vacuolar protein sorting 26 homolog A antibody; Vacuolar protein sorting 26 homolog A S. pombe antibody; Vacuolar protein sorting 26 homolog A yeast antibody; Vacuolar protein sorting 26 yeast antibody; Vacuolar protein sorting 26 yeast homolog antibody; Vacuolar protein sorting 26A antibody; Vacuolar protein sorting associated protein 26A antibody; Vacuolar protein sorting-associated protein 26A antibody; Vesicle protein sorting 26 antibody; Vesicle protein sorting 26A antibody; VP26A_HUMAN antibody; VPS 26 antibody; VPS 26A antibody; VPS26A antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Vacuolar protein sorting-associated protein 26A protein (21-180AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2A (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.
Gene References into Functions
  1. The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35, which are impaired in neurodegenerative diseases. (Review) PMID: 26965691
  2. Mutagenesis studies coupled with coimmunoprecipitations revealed that retromer-mediated trafficking requires the Env cytoplasmic tail that we show binds directly to retromer components Vps35 and Vps26. PMID: 25393110
  3. This study demonstrated that Genetic variability of VPS26A in parkinsonism. PMID: 25475142
  4. Mutations in the gene composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease. PMID: 24684791
  5. Mutations in VPS26A are not a frequent cause of Parkinson's disease. PMID: 24417787
  6. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection. PMID: 25136126
  7. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function PMID: 22284051
  8. Colocalization of Vps26 paralogues with different endosomally located Rab proteins shows prolonged association of Vps26B-retromer with maturing endosomes relative to Vps26A-retromer. PMID: 21920005
  9. These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles. PMID: 17101778
  10. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. PMID: 19531583

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Subcellular Location Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome.
Protein Families VPS26 family
Database Links

HGNC: 12711

OMIM: 605506

KEGG: hsa:9559

STRING: 9606.ENSP00000263559

UniGene: Hs.499925

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