VPS37A Antibody

Datasheet

Code	CSB-PA256766
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA256766(VPS37A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA256766(VPS37A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human bladder carcinoma and fetal liver tissue, Primary antibody: CSB-PA256766(VPS37A Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NEZ2

Target Names

VPS37A

Alternative Names

VPS37A antibody; HCRP1 antibody; Vacuolar protein sorting-associated protein 37A antibody; hVps37A antibody; ESCRT-I complex subunit VPS37A antibody; Hepatocellular carcinoma-related protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human VPS37A

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Gene References into Functions

HCRP1 is a negative regulator in prostate cancer progression, metastasis and multi-drug resistance. PMID: 28458158
this study identifies HCRP1 downregulation correlates with tumor stage, nodal metastasis, and poor patient survival in human gastric cancer PMID: 28963677
The present data indicate that HCRP1 inhibits breast cancer metastasis through downregulating EGFR phosphorylation. PMID: 27311861
Low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma who received preoperative chemoradiotherapy PMID: 22891969
The missense mutation c.1146A>T in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. PMID: 22717650
Data show hVps37A mRNA downregulation in ovarian cancer. PMID: 22016507
Our results strongly suggest that HCRP1 might be a growth inhibitory protein and associated with decreasing the invasion of HCC cells PMID: 14623289
HCRP1 is a subunit of mammalian ESCRT-I, and its function is essential for lysosomal sorting of EGF receptors. PMID: 15240819

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Involvement in disease

Spastic paraplegia 53, autosomal recessive (SPG53)

Subcellular Location

Late endosome membrane; Peripheral membrane protein. Nucleus.

Protein Families

VPS37 family

Tissue Specificity

Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.

Database Links

HGNC: 24928

OMIM: 609927

KEGG: hsa:137492

STRING: 9606.ENSP00000318629

UniGene: Hs.343873

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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