WAPAL Antibody

1. Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF sites. PMID: 28475897
2. Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer. PMID: 26722608
3. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53-dependent manner but causes p53-deficient cells to become highly aneuploid. PMID: 24055153
4. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin PMID: 23776203
5. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells PMID: 22751501
6. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain. PMID: 15383329
7. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits PMID: 17112726
8. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. PMID: 17113138
9. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. PMID: 17382297
10. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder. PMID: 18662753

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HGNC: 23293

OMIM: 610754

KEGG: hsa:23063

STRING: 9606.ENSP00000298767

UniGene: Hs.203099