WDR74 Antibody

Datasheet

Code	CSB-PA747557LA01HU
Size	US$166
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Image	Western blot All lanes: WDR74 antibody at 0.5µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 43, 41 kDa Observed band size: 43 kDa Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA747557LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA747557LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) WDR74 Polyclonal antibody

Uniprot No.

Q6RFH5

Target Names

WDR74

Alternative Names

WDR74 antibody; NSA1 antibody; WD repeat-containing protein 74 antibody; NOP seven-associated protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human WD repeat-containing protein 74 protein (111-366AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The WDR74 Antibody (Product code: CSB-PA747557LA01HU) is Non-conjugated. For WDR74 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA747557LB01HU	WDR74 Antibody, HRP conjugated	ELISA
FITC	CSB-PA747557LC01HU	WDR74 Antibody, FITC conjugated
Biotin	CSB-PA747557LD01HU	WDR74 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development.

Gene References into Functions

knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651

Subcellular Location

Nucleus, nucleolus. Nucleus.

Database Links

HGNC: 25529

OMIM: 617947

KEGG: hsa:54663

STRING: 9606.ENSP00000278856

UniGene: Hs.654620

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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