WDR74 Antibody, Biotin conjugated

Code CSB-PA747557LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WDR74 Polyclonal antibody
Uniprot No.
Target Names
WDR74
Alternative Names
WDR74 antibody; NSA1 antibody; WD repeat-containing protein 74 antibody; NOP seven-associated protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human WD repeat-containing protein 74 protein (111-366AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development.
Gene References into Functions
  1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
  2. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651
Subcellular Location
Nucleus, nucleolus. Nucleus.
Database Links

HGNC: 25529

OMIM: 617947

KEGG: hsa:54663

STRING: 9606.ENSP00000278856

UniGene: Hs.654620

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