WISP3 Antibody

1. WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells PMID: 29920361
2. WISP3 gene was associated with developmental dysplasia of the hip (DDH) in Chinese Han population. GGCGG haplotype might be a biomarker for DDH. PMID: 29680248
3. analysis of WISP3 mutations causing progressive pseudorheumatoid dysplasia in Jammu and Kashmir-India PMID: 27291587
4. These results demonstrate that CCN6 regulates epithelial and mesenchymal states transition and tumor initiating cells programs in breast cancer PMID: 26933820
5. two WISP3 mutations have been identified in two affected siblings by targeted NGS, thus permitting the clinical diagnosis of PPD. This case supports the utility of NGS in the genetic characterization of skeletal dysplasias, which in turn may aid their clinical care, permit predictive screening, and to provide genetic counselling to families. PMID: 26991965
6. CCN6 acts as a molecular brake, which is appropriately balanced by Nrf2, in regulating mitochondrial function. PMID: 27252383
7. Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer. PMID: 26498181
8. WISP3 harbored not only frameshift mutation but also mutational intratumoral heterogeneity and loss of expression, which together might play a role in tumorigenesis of GC and CRC with MSI-H by inhibiting tumor suppressor functions of WISP3. PMID: 26997449
9. WISP3 variant leads to the diagnosis of SEDT-PA. PMID: 26493744
10. Novel and recurrent mutations in WISP3 and an atypical phenotype have been described in Indian families with progressive pseudorheumatoid dysplasia. PMID: 25988854
11. A novel mutation c.667T>G (p.Cys223Gly) and the c.857C>G (p.Ser286*) mutation were detected in three Chinese patients with PPD. PMID: 25738435
12. This study identified 3 different WISP3 mutations in 2 unrelated Chinese families with spondyloepiphyseal dysplasia tarda with progressive arthropathy. PMID: 25553839
13. Suggest WISP3-Wnt/beta-catenin axis may have role in regulating gastric cancer cell proliferation and metastasis. PMID: 25400723
14. Novel C223G and C252X mutations in exon 4 of the WISP3 gene are responsible for progressive pseudorheumatoid dysplasia in Chinese patients. PMID: 25794430
15. Results are indicative of an operational WISP3-IGF1 regulatory loop whereby WISP3 preserves cartilage integrity by restricting IGF1-mediated hypertrophic changes in chondrocytes, at least partly, upon interaction with IGF1. PMID: 23424195
16. A report on 11 different homozygous mutations and one instance of compound heterozygosity in the WISP3 gene in patients with progressive pseudorheumatoid dysplasia. PMID: 22987568
17. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TbetaRIII in maintaining acinar organization in the breast. PMID: 23226100
18. Mutation analysis of WISP3 allowed the confirmation of the diagnosis in 63 out of 64 typical cases of progressive pseudorheumatoid dysplasia. PMID: 22791401
19. The data presented in this study reveal that CCN6 downregulation disrupts acinar morphogenesis and promotes invasion of mammary epithelial cells PMID: 22805309
20. Results indicate that WNT1-inducible signaling pathway protein 3 (WISP3) mutations are associated with progressive pseudorheumatoid dysplasia (PPD). PMID: 22685593
21. CCN6 was highly expressed in end-stage osteoarthritic cartilage, suggesting a role in cartilage homeostasis. CCN6-induced repression of ADAMTS-5 and regulation of MMP-10 expression suggest complex roles for CCN6 in cartilage biology. PMID: 22294415
22. The mutations of the WISP3 gene in Progressive pseudorheumatoid dysplasia are located in the range of exon 2 to exon 5. PMID: 21993478
23. demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397). PMID: 21921419
24. our results indicate that CCN6 enhances the migration of chondrosarcoma cells by increasing ICAM-1 expression PMID: 21391218
25. Data define a pathway in which CCN6 attenuates IGF-1 signaling to decrease ZEB1 expression and invasion in breast cancer. PMID: 21525039
26. KLK12 may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners PMID: 21628462
27. Homozygous recurring mutation in WISP3 causing progressive pseudorheumatoid arthropathy. PMID: 21528827
28. The expressions of Cyr61 and/or WISP-3 may be important biological markers in reflecting the progression, biological behaviors, metastatic potential and prognosis of NSCLC. PMID: 21159247
29. WISPs may play important but contrasting roles in colorectal cancer with WISP-1 appearing to act as a factor stimulating aggressiveness, WISP-2 as a tumour suppressor and WISP-3 having no definable beneficial or detrimental role PMID: 20372786
30. CCN6 (WISP3) blockade activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells PMID: 20395207
31. WISP3 and RhoC genes expression status defines a molecular signature of inflammatory breast cancer (IBC). PMID: 20014943
32. WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis. PMID: 12082632
33. WISP3 gene expression is higher in rheumatoid arthritis synovium and fibroblast-like synoviocytes compared with osteoarthritis and normal synovial tissue and is further induced by proinflammatory cytokines in vitro. PMID: 15517620
34. the WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice PMID: 15601861
35. WISP transcripts may have a role in the development of human hepatocellular carcinoma PMID: 15650268
36. stable inhibition of CCN6 expression in human mammary epithelial cells induces epithelial-mesenchymal transition, promotes anchorage-independent growth, motility and invasiveness, and sensitizes mammary epithelial cells to the growth effects of IGF-1 PMID: 16457688
37. WISP-3 may also promote superoxide dismutase expression and activity in chondrocytes PMID: 16480948
38. WISP3 regulates the accumulation of cellular reactive oxygen species, and mutations in WISP3 or loss of expression of WISP3 compromise this function. PMID: 17286957
39. Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF1 hypothesis of osteochondrodysplasias. PMID: 17363178
40. WISP-3 showed no statistically significant difference between groups. PMID: 17406949
41. Results show a compound heterozygous mutation of WISP3 and a series of cellular and molecular changes disturbing the endochondral ossification in this PPD patient. PMID: 17483925
42. These results lead to a new hypothesis that Snail and ZEB1 are downstream of CCN6 and play a critical role in CCN6-mediated regulation of E-cadherin in breast cancer. PMID: 18321996
43. novel G46X and C114Y mutations in exon 3 in WISP3 gene are responsible for PPD in Chinese patients PMID: 19064006

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HGNC: 12771

OMIM: 208230

KEGG: hsa:8838

STRING: 9606.ENSP00000354734

UniGene: Hs.558428