WNT10B Antibody

1. Treatment of secondary hyperparathyroidism with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level. PMID: 30149605
2. We report an Indian girl with split-hand/foot malformation (SHFM), sparse hair, and interrupted eyebrows, who carries a novel homozygous deletion c.695_697delACA in WNT10B. The variant is deduced to cause an in-frame deletion of Asn residue 232 (p.Asn232del). PMID: 29427788
3. Wnt10b is involved in forskolin/hCG-mediated BeWo cell fusion via beta-catenin/GCMa/syncytin pathway, which may also involve activation of PKA PMID: 28370659
4. These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene, as a relevant mechanism for Wnt involvement in human cancer. PMID: 27853307
5. High expression of WNT10B is associated with epithelial-mesenchymal transition and invasion of pancreatic cancer. PMID: 28586066
6. this study provides novel insight into the mechanism of action of parathyroid hormone on human periodontal ligament cells and establish their interplay with T cells via the Wnt10b pathway as a modulating factor for the anabolic properties of the hormone in periodontal regeneration PMID: 28071181
7. findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endothelial differentiation of dental pulp stem cells. PMID: 27321946
8. these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf pathway PMID: 25995040
9. Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts. PMID: 26338900
10. WNT10B enhances proliferation through beta-catenin and RAC1 GTPase in human corneal endothelial cells. PMID: 26370090
11. Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation. PMID: 24211389
12. No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found. PMID: 23325361
13. Variations in WNT10B do not contribute to human monogenic obesity in our population. PMID: 23104151
14. Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells. PMID: 23900840
15. we identified WNT10B as a direct target of miR-148a in cancer-associated fibroblasts from endometrial cancers PMID: 22890324
16. WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression. PMID: 23307470
17. Results suggest that Wnt10b likely plays an important role in the development of endometrial cancer (EC). The results also identify a role for Wnt10b in EC cells through promoting proliferation and inhibiting apoptosis. PMID: 23135473
18. A novel sequence variant (c.986C>G, p.Thr329Arg) of WNT10B has been identified in familial split-hand/foot malformations in a large consanguineous Pakistani family. PMID: 21554266
19. common variation in WNT10B was shown to be associated with BMI and weight in a case-control population of Belgian males. PMID: 22189080
20. Wnt10b, but not Wnt3a, stimulates the NFkappaB and Notch pathways in U2OS osteosarcoma cells. PMID: 21321991
21. This study is the first report of the association of common genetic polymorphism of WNT10B with human fat accumulation. PMID: 20579865
22. Homozygous nonsense mutation in WNT10B is associated with sporadic split-hand/foot malformation with autosomal recessive inheritance. PMID: 20635353
23. pyrethroid insecticides and estrogen can enhance the expression of the WNT10B proto-oncogene PMID: 12437293
24. mutations represent the first naturally occurring missense variants of WNT10B PMID: 16477437
25. suggest that fibroblast growth factor switches WNT10B from a negative to a positive cell growth regulator PMID: 17761539
26. Metastatic osteosarcoma cell lines showed better chemotaxis response to Wnt10B than the non-metastatic osteosarcoma cell lines PMID: 18465804
27. By homozygosity mapping a novel Split-Hand/Foot Malformation locus at 12q13.11-q13 with a maximum multipoint lod score of 5.47; by subsequent candidate gene approach a homozygous missense WNT10b mutation was identified. PMID: 18515319
28. This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry. PMID: 19016593
29. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this protein, suggesting Wnt-dependent regulation of p27(KIP1). PMID: 19056892
30. S1P induces osteoblast precursor recruitment and promotes mature cell survival. Wnt10b and BMP6 also were significantly increased in mature osteoclasts, whereas sclerostin levels decreased during differentiation. PMID: 19075223
31. We have not found evidence for a robust association of common WNT10B gene allelic variants with either BMD or fractures in postmenopausal women. PMID: 19458884

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HGNC: 12775

OMIM: 225300

KEGG: hsa:7480

STRING: 9606.ENSP00000301061

UniGene: Hs.91985