WNT7A Antibody

Datasheet
Code CSB-PA026141GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. O00755
Immunogen Human WNT7A
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias 39kd;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Target Names WNT7A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes.
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Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).
Involvement in disease Limb pelvis hypoplasia aplasia syndrome (LPHAS); Fuhrmann syndrome (FUHRS)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Wnt family
Tissue Specificity Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
Database Links

HGNC: 12786

OMIM: 228930

KEGG: hsa:7476

STRING: 9606.ENSP00000285018

UniGene: Hs.72290

Pathway Hippo signaling pathway
Melanogenesis
mTOR signaling pathway
Wnt signaling pathway
Signaling pathways regulating pluripotency of stem cells

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