WWP2 Antibody

1. The present study suggested that miR32 may effectively inhibit WWP2 expression in human amniotic epithelial stem cells and promote Oct4 overexpression to maintain their pluripotency. PMID: 29393344
2. Our study suggests that WWP2 may play a role in the genesis and development of glioma; it may be a potential biomarker to predict pathological grade and tumor recurrence in patients with glioma. PMID: 29237971
3. SNP rs62051384, located within WWP2, showed an association with plantar fascial disorders at genome-wide significance (p<5x10(-8)) with small effects (odds ratios=0.93 and 1.07 per allele, respectively). PMID: 29534260
4. Describe an autoinhibitory mechanism for WWP2 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation. PMID: 28475870
5. results provide evidence that WWP2 serves as a positive regulator of osteogenesis by augmenting RUNX2 transactivation in a non-proteolytic mono-ubiquitination manner. PMID: 28500134
6. Data suggest that elevated expression of WW domain containing E3 ubiquitin protein ligase 2 (WWP2) may play a role in facilitating the development of lung adenocarcinoma. PMID: 27462019
7. we demonstrate that WWP2 promotes cell adhesion, invasion, and migration in liver cancer by upregulating CXCR3 and CCR5 expression associated with the chemokine signaling pathway. PMID: 26662306
8. WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer. PMID: 26783238
9. majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 in ovarian carcinomas PMID: 25356737
10. Results identify WWP2 as a novel p73-associated protein that ubiquitinates and degrades p73. PMID: 25071155
11. Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
12. WWP2-N is downregulated in stage IIIC melanoma and up-regulated in stage II/III prostate cancer, and WWP2-FL and WWP2-C overexpression is associated with early-stage breast cancer. PMID: 23938591
13. Koala retrovirus Gag PPPY L-domain interacts with the WW domain(s) of WWP2 and progeny virions are released from cells by utilizing the multivesicular body sorting pathway. PMID: 23651516
14. WWP2 controls cellular apoptosis and is required for tumorigenicity of cells PMID: 21532586
15. Data show that the WWP2-N isoform interacts with Smad2 and Smad3, whereas WWP2-C interacts only with Smad7. PMID: 21258410
16. expression, binding, and functional data all suggest that WWP2 is a candidate to regulate ENaC-mediated Na(+) transport in epithelia PMID: 12167593
17. First demonstration of ubiquitin-protein ligase WWP2 from human lung cDNA library recruited by penton base proteins of adenovirus serotypes Ad2 and Ad3 in vitro and in vivo. PMID: 12450395
18. Data show that WWP2 and Nedd4-2 both bind to the cardiac sodium channel Na(v)1.5, but only Nedd4-2 robustly ubiquitinated and downregulated Na(v)1.5. PMID: 15548568
19. cIAP1 and cIAP2 promote cancer cell survival by functioning as E3 ubiquitin ligases that maintain constitutive ubiquitination of the RIP1 adaptor protein. PMID: 18570872
20. The WWP2 protein is an important regulator for maintaining a proper POU5F1 protein level in human Embryonic Stem Cells. PMID: 19274063
21. AIP2 regulates activation-induced T-cell death by suppressing EGR2-mediated FasL expression via the ubiquitin pathway PMID: 19651900

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HGNC: 16804

OMIM: 602308

KEGG: hsa:11060

STRING: 9606.ENSP00000348283

UniGene: Hs.408458