X Antibody

^{Rare Species}

Datasheet

Code	CSB-PA865559LA01HEO
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D) X Polyclonal antibody

Uniprot No.

Q9QMI3

Target Names

Alternative Names

X antibody; Protein X antibody; HBx antibody; Peptide X antibody; pX antibody

Raised in

Rabbit

Species Reactivity

Hepatitis B virus genotype D subtype ayw

Immunogen

Recombinant Hepatitis B virus genotype D subtype ayw Protein X protein (1-154AA)

Immunogen Species

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)

Conjugate

Non-conjugated

The X Antibody (Product code: CSB-PA865559LA01HEO) is Non-conjugated. For X Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA865559LB01HEO	X Antibody, HRP conjugated	ELISA
FITC	CSB-PA865559LC01HEO	X Antibody, FITC conjugated
Biotin	CSB-PA865559LD01HEO	X Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.

Subcellular Location

Host cytoplasm. Host nucleus. Host mitochondrion.

Protein Families

Orthohepadnavirus protein X family

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