XAB2 Antibody, HRP conjugated

Code CSB-PA862073LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) XAB2 Polyclonal antibody
Uniprot No.
Target Names
XAB2
Alternative Names
0610041O14Rik antibody; adapter protein ATH 55 antibody; Adapter protein ATH-55 antibody; Ath55 antibody; AV025587 antibody; Crn related protein kim1 antibody; crn-related protein kim1 antibody; DKFZp762C1015 antibody; HCNP antibody; HCNP protein antibody; HCRN antibody; KIAA1177 antibody; NTC90 antibody; PP3898 antibody; Pre-mRNA-splicing factor SYF1 antibody; Protein HCNP antibody; RNA splicing factor antibody; SYF1 antibody; SYF1 homolog antibody; SYF1 homolog, RNA splicing factor antibody; SYF1 pre mRNA splicing factor antibody; SYF1_HUMAN antibody; Xab2 antibody; XPA binding protein 2 antibody; XPA-binding protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pre-mRNA-splicing factor SYF1 protein (750-840AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
Gene References into Functions
  1. these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE. PMID: 27735937
  2. we suggest that the XAB2 complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function PMID: 27084940
  3. Study identifies XAB2 tagSNPs (rs794078 and rs4134816) significantly associated with the risk of non-small cell lung cancer (NSCLC) in Chinese population, which supports XAB2 playing significant role in the development of NSCLC. PMID: 26228655
  4. Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair and XAB2 expression. PMID: 25027282
  5. XAB2 complex is a multifunctional factor involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair. PMID: 17981804

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Subcellular Location
Nucleus.
Protein Families
Crooked-neck family
Database Links

HGNC: 14089

OMIM: 610850

KEGG: hsa:56949

STRING: 9606.ENSP00000351137

UniGene: Hs.9822

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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