ZBED3 Antibody, FITC conjugated

Code CSB-PA839344LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZBED3 Polyclonal antibody
Uniprot No.
Target Names
ZBED3
Alternative Names
MGC15435 antibody; ZBED3 antibody; ZBED3_HUMAN antibody; Zinc finger BED domain containing 3 antibody; Zinc finger BED domain-containing protein 3 antibody; Zinc finger BED type containing 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger BED domain-containing protein 3 protein (1-234AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression. Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network. Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation.
Gene References into Functions
  1. Zbed3 concentrations were significantly higher in metabolic syndrome patients compared with healthy subjects. Circulating Zbed3 concentrations were associated with glucose and lipid parameters, markers of adiposity, and blood pressure. PMID: 28346859
  2. Finally, the wnt-inhibitor DKK1 could reverse the stimulatory effect of ZBED3-AS1 on chondrogenesis. These findings demonstrate the role of a new lncRNA, ZBED3-AS1, in SFMSC chondrogenesis and may improve osteoarthritis treatment. PMID: 28431932
  3. results suggest that Zbed3 may contribute to lung cancer cell invasion through regulating beta-catenin and p120ctn-1 and may be a promissing cancer marker in non-small cell lung cancer PMID: 25263389
  4. results suggest that the Zbed3 protein may be a cytokine associated with insulin resistance in humans that is influenced by glucose and insulin levels. PMID: 24283382
  5. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation. PMID: 19141611

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Subcellular Location
Cytoplasm. Membrane. Secreted.
Tissue Specificity
Secreted in blood plasma, and expressed in skeletal muscle and adipose tissue (at protein level).
Database Links

HGNC: 20711

OMIM: 615250

KEGG: hsa:84327

UniGene: Hs.584988

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