ZBTB33 Antibody

1. The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines. Moreover, decreased expression of miR-4262 was closely related to increased expression of Kaiso (ZBTB33). PMID: 28800784
2. extracellular microenvironment signals regulate RhoH and Kaiso to modulate actin-cytoskeleton structure and transcriptional activity during T cell migration PMID: 27574848
3. Kaiso silencing had similar effects as miR-181a overexpression in glioma cells, whereas overexpression of Kaiso in glioma cells partially reversed the inhibitory effects of the miR-181a mimic. PMID: 30036882
4. data show that Kaiso favors an mCpG over a CpG site by 2 orders of magnitude in affinity and that an important component of this effect is the presence of hydrophobic and CH...O contacts involving E535. PMID: 29546986
5. High levels of nuclear Kaiso expression were detected in patients with a higher degree of African heritage compared to their Caucasian counterparts, suggesting a role for Kaiso in triple-negative breast cancer racial disparity. PMID: 28887687
6. Kaiso promotes Jagged-1 expression, which may have implications in Notch-mediated colon cancer progression PMID: 28637464
7. A role for Kaiso in the proliferation. PMID: 28333150
8. the pathological features of the metastatic activity of parental (Kaisopositive) versus Kaisodepleted MDA-231 cells, are reported. PMID: 28880889
9. Suggest a role for Kaiso in the progression of pancreatic ductal adenocarcinomas, involving the epithelial mesenchymal transformation markers, E-cadherin and Zeb1. PMID: 27424525
10. a novel mechanism by which ZBTB33 mediates the cyclin D1/cyclin E1/RB1/E2F pathway, controlling passage through the G1 restriction point and accelerating cancer cell proliferation. PMID: 27694442
11. GR is a putative target gene of Kaiso. PMID: 26424557
12. Kaiso high expression correlated with invasion of prostate cancer. PMID: 26734997
13. Results show that Kaiso binding to unmethylated Kaiso binding site in the human ICR1 is necessary for ICR1 methylation maintenance and affects transcription rates of the lncRNA H19. PMID: 27152123
14. Kaiso modulates HIF1A gene expression by binding to the methylated HIF1A promoter in a region proximal to the autoregulatory HIF-1 binding site, primarily during hypoxia. PMID: 26514431
15. NF-kappaB response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO and p53 PMID: 26183023
16. KAISO is a regulator of p53-mediated transcription of CDKN1A and apoptotic genes PMID: 25288747
17. Data indicate that Kaiso protein participates in the regulation of beta-catenin mRNA expression by interacting with p120-catenin in the lung cancer cell lines. PMID: 24498333
18. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. PMID: 24570268
19. The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling. PMID: 24474278
20. Transcription factor Kaiso does not interact with hydroxymethylated DNA within CTGCNA sequence context PMID: 23888785
21. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression PMID: 23251453
22. Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanism. PMID: 23226276
23. These findings establish a defined oncogenic role of Kaiso in promoting the progression of prostate cancer. PMID: 22974583
24. High cytoplasmic kaiso expression is associated with thymoma. PMID: 22833212
25. nuclear Kaiso is common in clinically aggressive ductal breast cancer, while cytoplasmic Kaiso and a p120-mediated relief of Kaiso-dependent transcriptional repression characterize invasive lobular carcinoma (ILC). PMID: 22662240
26. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso PMID: 22949637
27. Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition. PMID: 22590627
28. Data show that Kaiso requires all three zinc fingers plus adjacent protein regions for DNA recognition. PMID: 22300642
29. Results suggest that p120ctn isoforms 1 and 3 up-regulate cyclin D1, and thereby cyclin E, resulting in the promotion of cell proliferation and cell cycle progression in lung cancer cells. PMID: 22276175
30. when released from E-cadherin by Wnt3a-stimulated phosphorylation, p120-catenin controls the activity of Kaiso, enhancing its binding to repressed promoters and relieving its inhibition of the beta-catenin-Tcf-4 transcriptional complex. PMID: 21670201
31. Increased delta-catenin expression is critical for maintenance of the malignant phenotype of lung cancer, making delta-catenin a candidate target protein for future cancer therapeutics. PMID: 21070476
32. In endothelial cells, p120ctn has a transcription repression function through regulation of Kaiso, possibly as a cofactor with the transcription factor. PMID: 20382170
33. Data strongly imply that Kaiso's function as a transcriptional regulator might be linked to the control of the cell cycle and to cell proliferation in cancer. PMID: 20169156
34. Bifunctional role of domain zinc fingers of methyl-DNA-binding protein Kaiso PMID: 20586187
35. differential expression of p120(ctn) and Kaiso mRNA was observed in human coronary artery endothelial cells depending on how laminar shear stress was applied in relation to the wounding process PMID: 14699141
36. Kaiso translocates to the nucleus to regulate transcription of genes with diverse roles in cell growth and development PMID: 15564377
37. Data imply an unexpected influence of the microenvironment on Kaiso expression and localizationin colorectal adenocarcinoma. PMID: 15781635
38. Kaiso associates with the matrilysin promoter in vivo. PMID: 15817151
39. KAISO binds specifically to the methylated, but not the unmethylated, sequence in the first exon of the tyrosine hydroxylase [TH]gene and thus may play an important role in modulating human TH gene expresison. PMID: 15953356
40. the Kaiso-CTCF interaction negatively regulates CTCF insulator activity PMID: 16230345
41. Our study suggests that this gene is not implicated in the RTT molecular pathogenesis PMID: 16530985
42. p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7 PMID: 18653469
43. Kaiso represses methylated tumor suppressor genes and can bind in a methylation-dependent manner to the CDKN2A in human colon cancer cell lines. Kaiso depletion induced tumor suppressor gene expression without affecting DNA methylation levels. PMID: 18794111
44. Kaiso plays some specific role in centrosome assembly and function, which is not restricted to mitosis PMID: 19502788
45. Data suggest cytoplasmic Kaiso expression is associated with poor prognosis of NSCLC and various subcellular localizations of Kaiso may play differential biological roles in NSCLC. PMID: 19508730

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HGNC: 16682

OMIM: 300329

KEGG: hsa:10009

STRING: 9606.ENSP00000314153

UniGene: Hs.143604