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Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Gene References into Functions
Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease. PMID: 28115489
This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA. PMID: 27226629
ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort. PMID: 26266351
Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis. PMID: 24286297
The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry. PMID: 16009132
Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2). PMID: 22955283
phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner PMID: 22205987
NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events PMID: 12748172
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Subcellular Location
Nucleus.
Tissue Specificity
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.