ZC3HC1 Antibody

Code CSB-PA801246ESR2HU
Size US$166
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  • Western blot
    All lanes: ZC3HC1 antibody at 0.98µg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 56, 54, 48 kDa
    Observed band size: 54 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA801246ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA801246ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZC3HC1 Polyclonal antibody
Uniprot No.
Target Names
ZC3HC1
Alternative Names
hNIPA antibody; NIPA_HUMAN antibody; Nuclear interacting partner of ALK antibody; Nuclear interacting partner of anaplastic lymphoma kinase antibody; Nuclear-interacting partner of ALK antibody; Nuclear-interacting partner of anaplastic lymphoma kinase antibody; zc3hc1 antibody; Zinc finger C3HC type containing 1 antibody; Zinc finger C3HC-type protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear-interacting partner of ALK protein (1-260AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Gene References into Functions
  1. Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease. PMID: 28115489
  2. This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA. PMID: 27226629
  3. ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort. PMID: 26266351
  4. Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis. PMID: 24286297
  5. The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry. PMID: 16009132
  6. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2). PMID: 22955283
  7. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner PMID: 22205987
  8. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events PMID: 12748172

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Subcellular Location
Nucleus.
Tissue Specificity
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
Database Links

HGNC: 29913

KEGG: hsa:51530

STRING: 9606.ENSP00000351052

UniGene: Hs.194157

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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