ZDHHC6 Antibody

Code CSB-PA862029LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: NIH/3T3 whole cell lysate, HL-60 whole cell lysate, RAW264.7 whole cell lysate
    All lanes: ZDHHC6 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 48 kDa
    Observed band size: 48 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZDHHC6 Polyclonal antibody
Uniprot No.
Target Names
ZDHHC6
Alternative Names
ZDHHC6; ZNF376; Palmitoyltransferase ZDHHC6; Stearoyltransferase ZDHHC6; Transmembrane protein H4; Zinc finger DHHC domain-containing protein 6; DHHC-6; Zinc finger protein 376
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Palmitoyltransferase ZDHHC6 protein (227-409AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ZDHHC6 Antibody (Product code: CSB-PA862029LA01HU) is Non-conjugated. For ZDHHC6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA862029LB01HU ZDHHC6 Antibody, HRP conjugated ELISA
FITC CSB-PA862029LC01HU ZDHHC6 Antibody, FITC conjugated
Biotin CSB-PA862029LD01HU ZDHHC6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation.
Gene References into Functions
  1. human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade. PMID: 28826475
  2. DHHC6 knockdown using shRNA in stably transfected cell lines led to decreased expression of the IP3R and impaired IP3R-dependent Ca(2+) flux. PMID: 25368151
  3. Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain. PMID: 19801377
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
DHHC palmitoyltransferase family
Database Links

HGNC: 19160

KEGG: hsa:64429

STRING: 9606.ENSP00000358413

UniGene: Hs.196990

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