ZDHHC7 Antibody

Code CSB-PA002138
Size US$167
Image
  • Western Blot analysis of HuvEc cells using DHHC-7 Polyclonal Antibody
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Product Details

Uniprot No. Q9NXF8
Target Names ZDHHC7
Alternative Names ZDHHC7 antibody; Palmitoyltransferase ZDHHC7 antibody; EC 2.3.1.225 antibody; Zinc finger DHHC domain-containing protein 7 antibody; DHHC-7 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the C-terminal region of Human DHHC-7.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones
Gene References into Functions
  1. identified DHHC7 as a JAM-C palmitoylating enzyme PMID: 28196865
  2. The ZDHHC7-mediated SCRIB palmitoylation is critical for SCRIB membrane targeting, cell polarity and tumor suppression, providing new mechanistic insights of how dynamic protein palmitoylation regulates cell polarity and tumorigenesis. PMID: 27380321
  3. DHHC7-mediated palmitoylation of Fas allows a proper Fas expression level by preventing its degradation through the lysosomes. PMID: 25301068
  4. the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function PMID: 22031296
Subcellular Location Golgi apparatus membrane, Multi-pass membrane protein
Protein Families DHHC palmitoyltransferase family
Database Links

HGNC: 18459

OMIM: 614604

KEGG: hsa:55625

UniGene: Hs.461610

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