ZFP42 Antibody, Biotin conjugated

Code CSB-PA856985LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZFP42 Polyclonal antibody
Uniprot No.
Target Names
ZFP42
Alternative Names
hREX-1 antibody; Reduced Expression 1 Protein antibody; Reduced expression protein 1 antibody; Rex-1 antibody; REX1 antibody; REX1 transcription factor antibody; Zfp-42 antibody; Zfp42 antibody; ZFP42 zinc finger protein antibody; ZFP42_HUMAN antibody; Zinc finger protein 42 homolog antibody; Zinc finger protein 754 antibody; ZNF754 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger protein 42 homolog protein (6-68AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.
Gene References into Functions
  1. Results provide evidence that bFGF regulates stemness maintenance in stem cells isolated from human exfoliated deciduous teeth (SHEDs) by enhancing REX-1 mRNA expression via the FGFR and Akt signaling pathways. Moreover, IL-6 is also involved in the bFGF-induced REX1 expression. PMID: 27883224
  2. Results show that a novel pluripotency regulator, REX1, is essential for pluripotency and reprogramming. PMID: 23939908
  3. reduced expression protein-1 (REX-1) is widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. PMID: 21446939
  4. hRex1 binds to the hRex1 promoter region at -298 bp and positively regulates hRex1 transcription, but this regulation is lost in PC-3 human prostate cancer cells. PMID: 20232320
  5. REX1 functions in normal adult epithelial cells and tumorigenic stem cells. PMID: 16865673
  6. Data show that Oct-4, Rex-1, and Gata-4 expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression. PMID: 17211834
  7. expression of REX-1 in meiotic cells from both testes and ovary indicate a role in meiosis. PMID: 18281244
  8. MAPCs express the OCT4 and REX1 transcription factors, two specific markers of undifferentiated embryonic stem (ES) cells. PMID: 15790780

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Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem ce
Database Links

HGNC: 30949

OMIM: 614572

KEGG: hsa:132625

STRING: 9606.ENSP00000317686

UniGene: Hs.335787

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