ZFYVE9 Antibody

1. we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
2. SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
3. PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
4. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
5. TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
6. no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
7. SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
8. After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
9. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
10. role in rab5 mediated endocytosis PMID: 12432064
11. SARA MH2 domains function in TGF-beta signaling PMID: 15231848
12. internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
13. SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
14. Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
15. SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243

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HGNC: 6775

OMIM: 603755

KEGG: hsa:9372

STRING: 9606.ENSP00000287727

UniGene: Hs.532345