ZNF750 Antibody

Code CSB-PA027012GA01HU
Size $600
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
ZNF750
Alternative Names
ZNF750 antibody; Zinc finger protein 750 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human ZNF750
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.
Gene References into Functions
  1. ZNF750 acts as a potential tumor suppressor gene, and regulates tumor microenvironment. PMID: 29890464
  2. The low expression of ZNF750 was significantly associated with a poor prognosis. PMID: 29216641
  3. ZNF750 expression predicts sensitivity to CRT and can be a biomarker that reliably predicts the response of ESCC to CRT. PMID: 28558382
  4. ZNF750 Mutation is associated with esophageal squamous cell carcinoma. PMID: 27749841
  5. Suggest no connection of ZNF750 variants with psoriasis or its subphenotypes. PMID: 24005976
  6. ZNF750 thus controls differentiation in concert with RCOR1 and CTBP1/2 by acting with either KDM1A to repress progenitor genes or KLF4 to induce differentiation genes. PMID: 25228645
  7. ZNF750 was specifically expressed in the epidermal suprabasal layers and its expression was augmented during differentiation, both in human skin and in-vitro, peaking in the granular layer. PMID: 22936986
  8. ZNF750 directly links a tissue-specifying factor, p63, to an effector of terminal differentiation, KLF4. PMID: 22364861
  9. Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis. PMID: 22185198
  10. ZNF750 mutations could contribute to psoriasis susceptibility. PMID: 18256691

Show More

Hide All

Involvement in disease
Seborrhea-like dermatitis with psoriasiform elements (SLDP)
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.
Database Links

HGNC: 25843

OMIM: 610226

KEGG: hsa:79755

STRING: 9606.ENSP00000269394

UniGene: Hs.464391

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*