ZNF750

ZNF750, a zinc finger protein transcription factor, is active in differentiated keratinocytes and plays a crucial role in managing immune and inflammatory responses. By directly influencing immune reactions, ZNF750 can trigger a robust immune response when its expression is reduced in keratinocytes, leading to heightened PRRs gene expression and the release of numerous cytokines and chemokines. Conversely, its overexpression in undifferentiated keratinocytes can suppress immune responses. ZNF750 fosters skin immune tolerance and prevents chronic and excessive skin inflammation, particularly in conditions like psoriasis. Additionally, ZNF750 functions as a lineage-specific tumor suppressor in squamous cell carcinoma by regulating key cancer-related proteins such as TINCR and LAMC2.

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Recombinant Human Zinc finger protein 750 (ZNF750)