cyp125 Antibody

Code CSB-PA351308HA01MVZ
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cyp125 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
cyp125 antibody; cyp125A1 antibody; Rv3545c antibody; MTCY03C7.11Steroid C26-monooxygenase antibody; EC antibody; Cholest-4-en-3-one 26-monooxygenase antibody; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] antibody; Cholesterol C26-monooxygenase antibody; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] antibody; Cytochrome P450 125 antibody; Steroid C27-monooxygenase antibody
Raised in
Species Reactivity
Mycobacterium tuberculosis
Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA)
Immunogen Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

The cyp125 Antibody (Product code: CSB-PA351308HA01MVZ) is Non-conjugated. For cyp125 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA351308HB01MVZ cyp125 Antibody, HRP conjugated ELISA
FITC CSB-PA351308HC01MVZ cyp125 Antibody, FITC conjugated
Biotin CSB-PA351308HD01MVZ cyp125 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
Gene References into Functions
  1. M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation PMID: 26197389
  2. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. PMID: 25591012
  3. CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one. PMID: 20545858
  4. Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable. PMID: 19146393
  5. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. PMID: 19846551
  6. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. PMID: 19846552

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Protein Families
Cytochrome P450 family
Database Links

KEGG: mtu:Rv3545c

STRING: 83332.Rv3545c

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