cyp125 Antibody

^{Rare Species}

Datasheet

Code	CSB-PA351308HA01MVZ
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cyp125 Polyclonal antibody

Uniprot No.

P9WPP1

Target Names

cyp125

Alternative Names

cyp125 antibody; cyp125A1 antibody; Rv3545c antibody; MTCY03C7.11Steroid C26-monooxygenase antibody; EC 1.14.15.29 antibody; Cholest-4-en-3-one 26-monooxygenase antibody; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] antibody; Cholesterol C26-monooxygenase antibody; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] antibody; Cytochrome P450 125 antibody; Steroid C27-monooxygenase antibody

Raised in

Rabbit

Species Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA)

Immunogen Species

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Conjugate

Non-conjugated

The cyp125 Antibody (Product code: CSB-PA351308HA01MVZ) is Non-conjugated. For cyp125 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA351308HB01MVZ	cyp125 Antibody, HRP conjugated	ELISA
FITC	CSB-PA351308HC01MVZ	cyp125 Antibody, FITC conjugated
Biotin	CSB-PA351308HD01MVZ	cyp125 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.

Gene References into Functions

M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation PMID: 26197389
Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. PMID: 25591012
CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one. PMID: 20545858
Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable. PMID: 19146393
Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. PMID: 19846551
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. PMID: 19846552

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Protein Families

Cytochrome P450 family

Database Links

KEGG: mtu:Rv3545c

STRING: 83332.Rv3545c

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Tuberculosis--A Resurgent Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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