gH Antibody

Datasheet

Code	CSB-PA319015LA01HWV
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Human cytomegalovirus gH Polyclonal antibody

Uniprot No.

P12824

Target Names

Alternative Names

gH antibody; UL75 antibody; Envelope glycoprotein H antibody; gH antibody

Raised in

Rabbit

Species Reactivity

Human cytomegalovirus

Immunogen

Recombinant Human cytomegalovirus Envelope glycoprotein H protein (24-195AA)

Immunogen Species

Human cytomegalovirus

Conjugate

Non-conjugated

The gH Antibody (Product code: CSB-PA319015LA01HWV) is Non-conjugated. For gH Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA319015LB01HWV	gH Antibody, HRP conjugated	ELISA
FITC	CSB-PA319015LC01HWV	gH Antibody, FITC conjugated
Biotin	CSB-PA319015LD01HWV	gH Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The recombinant human cytomegalovirus (hCMV) envelope glycoprotein H (gH) protein (24-195AA) is used to immunize rabbits to generate the anti-gH antibody. The resulting antibody is a polyclonal antibody and exists as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it only reacts with the hCMV sample. The target protein gH is a component of the hCMV glycoprotein complex and dimerizes with gL to form the heterodimer gH-gL that is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. This gH antibody is suitable for the detection of gH protein in ELISA analysis.

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Target Background

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA. The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2.

Subcellular Location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein.

Protein Families

Herpesviridae glycoprotein H family

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