oxyR Antibody

Datasheet

Code	CSB-PA364842XA11ENV
Size	US$166
	Order now
Image	Western Blot Positive WB detected in: recombinant protein All lanes: oxyR Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa
The Latest Promotion
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P0ACQ4

Target Names

oxyR

Alternative Names

Hydrogen peroxide-inducible genes activator (Morphology and auto-aggregation control protein), oxyR, momR mor

Species Reactivity

E.coli

Immunogen

Recombinant E.coli oxyR protein (1-94aa)

Immunogen Species

Escherichia coli(strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The oxyR polyclonal antibody is produced by immunizing a rabbit with the recombinant E.coli oxyR protein (1-94aa), leading to the generation of antibodies specific to this antigen. A booster injection further boosts antibody production. Serum containing oxyR polyclonal antibodies is then collected and purified through affinity chromatography. The antibody's specificity for E.coli oxyR protein has been extensively validated through ELISA and WB assays.

The E. coli oxyR protein is a transcription factor that plays a central role in responding to oxidative stress by regulating the expression of genes involved in defense against reactive oxygen species (ROS). It protects the E. coli from the damaging effects of oxidative stress.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability.

Gene References into Functions

Constitutive expression of the OxyR regulon confers the maximum HOCl resistance. PMID: 24899627
The isogenic oxyR mutant exhibited increased H2O2 sensitivity, indistinguishable in vitro growth, and attenuated virulence in rodent models of urinary tract, subcutaneous infection, and systemic sepsis. PMID: 23850958
OxyR serves as a master regulator of S-nitrosylation, and alternative posttranslational modifications of OxyR control distinct transcriptional responses PMID: 22539721
OxyR seems to be a factor stimulating lambda prophage maintenance under conditions of oxidative stress. PMID: 20559623
Data suggest that the redox state of OxyR and Fnr modulates their interaction with the vgb promoter. PMID: 20025616
OxyR activation requires specific disulfide bond formation and that the rapid kinetic reaction path and conformation strain, respectively, drive the oxidation and reduction of OxyR PMID: 15543158
OxyR binds to cis-acting oxidant-responsive elements of the sufA promoter under oxidative stress conditions. PMID: 16824106
Molecular dynamics (MD) simulations have been performed on the regulatory domain of the Escherichia coli OxyR transcription factor for the different chemical states along the mechanistic cycle for its activation by hydrogen peroxide. PMID: 17036142
deletion mutant strains fail to enhance oxidative stress resistance following treatment with tannin and quercetin PMID: 19135521
study examined the contribution of residues at the dimer interface of the transcriptional regulator OxyR to oligomerization PMID: 19177355

Hide All

Database Links

KEGG: ecj:JW3933

STRING: 316385.ECDH10B_4150

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs) Effects of FSHR on Fertility and Tumors Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address