ptxA Antibody

Datasheet

Code	CSB-PA356423LA01Bua
Size	US$166
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Image	Western blot All lanes: Bordella pertussis pertussis toxin subunit 1 antibody at 2μg/ml + recombinant Bordella pertussis pertussis toxin subunit 1 100ng Secondary Goat polyclonal to rabbit IgG at 1/1000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Bordetella pertussis ptxA Polyclonal antibody

Uniprot No.

P04977

Target Names

ptxA

Alternative Names

ptxA antibody; BP3783 antibody; Pertussis toxin subunit 1 antibody; PTX S1 antibody; Islet-activating protein S1 antibody; IAP S1 antibody; NAD-dependent ADP-ribosyltransferase antibody; EC 2.4.2.- antibody

Raised in

Rabbit

Species Reactivity

Bordetella pertussis

Immunogen

Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA)

Immunogen Species

Bordetella pertussis

Conjugate

Non-conjugated

The ptxA Antibody (Product code: CSB-PA356423LA01Bua) is Non-conjugated. For ptxA Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA356423LB01Bua	ptxA Antibody, HRP conjugated	ELISA
FITC	CSB-PA356423LC01Bua	ptxA Antibody, FITC conjugated
Biotin	CSB-PA356423LD01Bua	ptxA Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The ptxA antibody is a polyclonal antibody produced in rabbit, which specifically binds to the Bordetella pertussis ptxA protein. The immunogen is a synthetic peptide mapping to the amino acids 35-269 of the recombinant Bordetella pertussis Pertussis toxin subunit 1 protein. The antibody has been purified using protein G affinity chromatography, resulting in a purity level greater than 95%. The antibody is of the IgG class and is unconjugated, meaning it can be used in a wide range of applications.

The ptxA antibody has been validated for use in both ELISA and WB applications. As a result, it is a valuable tool for researchers investigating Bordetella pertussis ptxA and its role in the pathogenesis of whooping cough.

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Target Background

Function

S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.

Gene References into Functions

It has been proposed that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. PMID: 28784932

Subcellular Location

Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.

Protein Families

Bacterial exotoxin subunit A family

Database Links

KEGG: bpe:BP3783

STRING: 257313.BP3783

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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