speB Antibody

Datasheet
Code CSB-PA314886LA01SMR
See More Details Free Antibody trial simple
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Uniprot No. P0C0J0
Image
  • Western Blot
    Positive WB detected in Recombinant protein
    All lanes: speB antibody at 3.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 44 kDa
    Observed band size: 44 kDa

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Recombinant Streptococcus pyogenes Streptopain protein (146-398AA)
Raised in Rabbit
Species Reactivity Streptococcus pyogenes
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:5000
Relevance Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP), speB
Immunogen Species Streptococcus pyogenes
Research Area Others
Target Names speB
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
Subcellular Location Secreted
Protein Families Peptidase C10 family

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