Recombinant Apis mellifera Phospholipase A2

This Recombinant Apis mellifera Phospholipase A2 was produced in E.coli, where the gene sequence encoding Apis mellifera Phospholipase A2 (34-167aa) was expressed with the N-terminal 6xHis tag. The purity of this Phospholipase A2 was greater than 85% by SDS-PAGE.
Phospholipase A2, abbreviated as PLA2, is a class of enzymes with its primary function being the hydrolysis of phospholipids, a major type of lipid present in cell membranes, to produce free fatty acids and soluble phospholipids. This process plays a crucial role in the metabolism of cell membranes, cell signal transduction, and inflammatory responses.
PLA2 also plays a role in the defense mechanisms of bees. Bee stings contain venom that includes proteins like PLA2, which are used to defend against predators. These proteins may cause the cell membranes of adversaries to rupture, leading to pain and an inflammatory response.
Proteins like PLA2 are also of significant value in medical research because they are associated with inflammatory conditions, neurological disorders, and other diseases. Some drugs and treatment approaches target PLA2 enzymes in the search for ways to treat inflammatory diseases.