Recombinant Bovine Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPARGC1A) ,partial

Code CSB-YP772944BO
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Source Yeast
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Code CSB-EP772944BO
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Source E.coli
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Code CSB-EP772944BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP772944BO
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Source Baculovirus
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Code CSB-MP772944BO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names PPARGC1A
Uniprot No. Q865B7
Alternative Names PPARGC1A; PGC1; PGC1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha
Species Bos taurus (Bovine)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
Gene References into Functions
  1. PPARGC1A single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle. PMID: 27468856
  2. regulatory role in intramuscular fat deposition PMID: 24778332
  3. The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age. PMID: 24197695
  4. PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits. PMID: 23342912
  5. NO/protein kinase G (PKG)-dependent downregulation of PGC-1 alpha and the ROS detoxification system in endothelial cells are mediated by the PI3K/Akt signaling PMID: 20547753
  6. The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported. PMID: 20154154
  7. Data show that two SNPs (Single Nucleotide Polymorphisms) were identified within exon 8 by multiple alignment of DNA sequences obtained from 24 bulls: a transition G/A (SNP 1181) and a transversion A/T (SNP 1299). PMID: 19665052
  8. genetic analysis of bovine PPARGC1A PMID: 15781588
  9. PPARGC1A was associated with a significant increase in milk protein percentage in contrast to association results previously reported for the German Holstein population PMID: 17517737

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Subcellular Location Nucleus. Nucleus, PML body.
Database Links

KEGG: bta:338446

STRING: 9913.ENSBTAP00000048844

UniGene: Bt.20920

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