PPARGC1A

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha is a protein in humans that is encoded by PPARGC1A gene. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

PPARGC1A Antibodies

PPARGC1A Antibodies for Homo sapiens (Human)

PPARGC1A Proteins

PPARGC1A Proteins for Mus musculus (Mouse)

PPARGC1A Proteins for Bos taurus (Bovine)

PPARGC1A Proteins for Sus scrofa (Pig)

PPARGC1A Proteins for Homo sapiens (Human)

PPARGC1A Proteins for Rattus norvegicus (Rat)

PPARGC1A ELISA Kit

PPARGC1A ELISA Kit for Homo sapiens (Human)

PPARGC1A ELISA Kit for Rattus norvegicus (Rat)

PPARGC1A ELISA Kit for Mus musculus (Mouse)

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