Recombinant Danio rerio BRCA1-A complex subunit BRE(bre)

Product Type Recombinant Protein
Uniprot No. Q568D5
Abbreviation bre
Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names babam2
Protein Names Recommended name: BRCA1-A complex subunit BRE Alternative name(s): BRCA1/BRCA2-containing complex subunit 45 Brain and reproductive organ-expressed protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Location Cytoplasm, Nucleus
Protein Families BABAM2 family
Database Links

KEGG: dre:550474

STRING: 7955.ENSDARP00000056741

UniGene: Dr.118971

Product Details for Different Expression Systems

Product Name Recombinant Danio rerio BRCA1-A complex subunit BRE(bre),Yeast
Code CSB-YP704077DIL
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Expression Region 1-386
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Danio rerio BRCA1-A complex subunit BRE(bre),E.coli
Code CSB-EP704077DIL
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Expression Region 1-386
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Danio rerio BRCA1-A complex subunit BRE(bre),Baculovirus
Code CSB-BP704077DIL
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Expression Region 1-386
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Danio rerio BRCA1-A complex subunit BRE(bre),Mammalian cell
Code CSB-MP704077DIL
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
Expression Region 1-386
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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