Recombinant Dog Ciliary neurotrophic factor receptor subunit alpha(CNTFR)

Product Type Recombinant Protein
Uniprot No. Q71DR4
Abbreviation CNTFR
Species Canis lupus familiaris (Dog) (Canis familiaris)
Gene Names CNTFR
Protein Names Recommended name: Ciliary neurotrophic factor receptor subunit alpha Short name= CNTF receptor subunit alpha Short name= CNTFR-alpha
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
HGNC 2170
RGD 1303100
MGI 99605
Function Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Protein Families Type I cytokine receptor family, Type 3 subfamily
Tissue Specificity Expressed in retina, brain, spleen, lung, liver and kidney. In the retina it is highly expressed by photoreceptors, but also found in the RPE, inner nuclear layer and ganglion cells.
Database Links

KEGG: cfa:442941

STRING: 9615.ENSCAFP00000002838

UniGene: Cfa.3908

Pathway Jak-STAT signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Dog Ciliary neurotrophic factor receptor subunit alpha(CNTFR),Yeast
Code CSB-YP754637DO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GS
Expression Region 23-342
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Ciliary neurotrophic factor receptor subunit alpha(CNTFR),E.coli
Code CSB-EP754637DO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GS
Expression Region 23-342
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Ciliary neurotrophic factor receptor subunit alpha(CNTFR),Baculovirus
Code CSB-BP754637DO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GS
Expression Region 23-342
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Ciliary neurotrophic factor receptor subunit alpha(CNTFR),Mammalian cell
Code CSB-MP754637DO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GS
Expression Region 23-342
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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