Recombinant Drosophila melanogaster Transcription factor glial cells missing (gcm), partial

1. study identifies a new molecular pathway in female reproductive system development and suggests a role for hGCM in the progression of reproductive tract diseases in humans PMID: 27886257
2. Frazzled expression is induced by the transcription factor Glide/Gcm in a dose-dependent manner. PMID: 27740455
3. Authors discuss the mode of action of Gcm in the different systems and present new tissues that require Gcm and we revise the concept of 'master gene'. PMID: 27434165
4. DNA adenine methyltransferase identification (DamID) identification of Gcm direct targets in Drosophila PMID: 26567182
5. Two missense alleles of gcm have been characterized and show the protein activities have been attenuated such that they are operating at threshold levels, and trigger glial cell differentiation in neural precursors in a stochastic fashion. PMID: 25044731
6. GCM directly regulates SIMU expression. gcm and repo have a critical role in controlling glial phagocytic function through regulation of SIMU and DRPR specific expression. PMID: 25046770
7. mutations in PcG components and in TrxG members found in chromatin remodeling complexes enhance the gcm dominant phenotype, suggesting a balanced action of these chromatin modifiers regulate Gcm function PMID: 23300465
8. The transcriptional activator Gcm constitutes a paradigmatic example of master regulator, acting as a pivotal cell fate determinant and differentiation factor during Drosophila embryogenesis. PMID: 23276603
9. Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia PMID: 21852399
10. expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis PMID: 11901125
11. Genome-wide analysis of downstream genes of gcm in the embryonic nervous system. Data Supports a model where gcm promotes glial development by activating glial genes while simultaneously repressing neuronal genes. PMID: 12091301
12. gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila PMID: 12167411
13. Gcm regulates glial development in Drosophila PMID: 12765609
14. Results indicate that glial cells missing transcription is controlled by a combination of general and lineage-specific elements, positive autoregulation, and neuronal repression. PMID: 14738884
15. glide/gcm triggers a new molecular pathway involved in terminal tendon cell differentiation, which allows the establishment of functional muscle attachment sites and locomotion PMID: 15342477
16. Gcm acts synergistically with other factors to control repo transcription in glial cells PMID: 15939231
17. gcm is initially expressed in all prohemocytes but is rapidly downregulated in the anterior-most row of prohemocytes PMID: 16176949
18. Gcm and Gcm2 are expressed in both glial and neuronal precursors within the optic lobe and autonomously regulate both glial and neuronal development in the visual system. PMID: 16242405
19. Huckebein does not activate transcription; rather, it physically interacts with Glide/Gcm thereby triggering its autoregulation. PMID: 16362045
20. gcm and gcm2 are expressed in precursors and postmitotic, migrating, cells of the medulla neuropile glia (mng) lineage, and also in a thoracic glial lineage and in neurons of the ventral nerve cord PMID: 17654713
21. Adenosine- and uridine-rich elements located in the 3'untranslated region of glial cells missing (gcm) master gene are directly involved in RNA decay. PMID: 18313940
22. Downregulation of Gcm protein levels by Slimb and Ago is required for glial progenitors to exit the cell cycle for differentiation. PMID: 19346490
23. To find potential partners of Gcm which trigger other pathways, we performed a yeast two-hybrid screen and identified dpias, a gene involved in post-embryonic hematopoiesis. PMID: 19598118

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KEGG: dme:Dmel_CG12245

STRING: 7227.FBpp0079451

UniGene: Dm.4757