Recombinant Drosophila melanogaster Tyrosine-protein kinase hopscotch (hop), partial

1. dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis. PMID: 28045022
2. Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling. PMID: 28424232
3. These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms. PMID: 28237966
4. Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. PMID: 28743877
5. Our study shows that haemocytes express the three upd genes and that injury markedly induces the expression of upd3 by the JNK pathway in haemocytes, which in turn activates the JAK/STAT pathway in the fat body and the gut. Surprisingly, release of Upd3 from haemocytes upon injury can remotely stimulate stem cell proliferation and the expression of Drosomycin-like genes in the intestine. PMID: 27231872
6. Hop is a critical component of the piRNA pathway and that it maintains genome integrity by silencing transposons. PMID: 28193840
7. these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis PMID: 25923769
8. Our work indicates that Slit-Robo signaling affects stem cell function downstream of the JAK-STAT pathway by controlling the ability of stem cells to compete for occupancy in their niche. PMID: 25375180
9. JAK/STAT signaling is critical for hinge fate specification and growth of the gap domain and that its restriction to the hinge is required for proper wing development PMID: 23978534
10. Molecular components of JAK/STAT signaling pathway and its connection with transcription machinery PMID: 23888769
11. Activation of JAK/STAT signaling pathway in S2 Drosophila melanogaster cell culture PMID: 23888780
12. A functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism. PMID: 23462467
13. dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. PMID: 23364332
14. Jak-STAT signaling from the hub acts on both GSCs and CySC to regulate their development and differentiation, and that additional signaling from CySCs to the GSCs play a dominant role in controlling GSC maintenance during niche formation. PMID: 23010510
15. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. PMID: 23172913
16. Studies identify miR-279 as a component of a feedback pathway that further dampens the response in cells with low levels of JAK/STAT activity. PMID: 21857668
17. the JAK/STAT pathway is necessary and sufficient for optic lobe neuroepithelial growth. PMID: 21651897
18. Data suggest that ISC self-renewal is cooperatively controlled by EGFR, Wg and JAK/STAT signaling pathway activities. PMID: 21440535
19. not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required PMID: 21518857
20. Data show that isolated plasmatocytes can be triggered to differentiate into lamellocytes in vitro, either in response to Chn over-expression, or following activation of the JAK/STAT pathway. PMID: 21124962
21. Dome signals both from the plasma membrane and internalised vesicles and show, using knockdown experiments, that endocytic components negatively regulate JAK-STAT signalling in vivo PMID: 20841381
22. identified eye transformer as a novel negative regulator of the Drosophila JAK/STAT pathway both in vitro and in vivo PMID: 20624926
23. Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway. PMID: 20348097
24. These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche. PMID: 20143337
25. JAK/STAT pathway functions cooperatively and in parallel with Wg signaling to control intestinal stem cells self-renewal. PMID: 19797317
26. activated by unpaired to specify self-renewal and continual maintenance of the germ line stem cell population PMID: 11752574
27. Upd in testis hub cells activates the JAK-STAT pathway in adjacent stem cells PMID: 11752575
28. By clonal analysis for Stat92E and hop (Drosophila JAK) mutants we find that the JAK/STAT pathway is required in border cells for their migration PMID: 11804783
29. requires the raf pathway to promote blood cell activation and differentiation PMID: 11919715
30. The difference in effect between localized expression of ligand (Unpaired) and dominant active JAK (Hopscotch) demonstrates that the ligand plays a cell non-autonomous role in hindgut cell rearrangement. PMID: 12441298
31. Four key components of the JAK/STAT pathway have been identified: Unpaired, a secreted ligand; Domeless, a cytokine-like receptor; Hopscotch, a JAK kinase; and Stat92E, a STAT transcription factor PMID: 14668372
32. A genetic analysis was made of Hop to larval hemocyte concentration and the egg encapsulation response. PMID: 15082553
33. dHop binds Hsp70 and Hsp90 and can rescue the growth defect in yeast. PMID: 15632128
34. Accumulation of STAT protein and nuclear accumulation are positively regulated by JAK/STAT activity. PMID: 16000386
35. hop signalling controls cell motility during germ cell migration. PMID: 16477645
36. Study shows that although STAT directly regulates Sxl establishment promoter (SxlPe), it is dispensable for promoter activation; instead, JAK/STAT is needed to maintain high-level SxlPe expression in order to ensure Sxl autoregulation in XX embryos. PMID: 17363251
37. main function of the JAK/STAT pathway in leg and antennal development is to promote the formation of a single proximo-distal axis per disc by constraining the intersection of wingless and decapentaplegic to the center of the disc. PMID: 17626283
38. The JAK/STAT pathway functions downstream/independently of cap cell formation induced by Notch signaling. JAK/STAT signaling may also regulate dpp expression in the male GSC niche, suggesting a common origin of female and male GSC niches. PMID: 18283115

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KEGG: dme:Dmel_CG1594

STRING: 7227.FBpp0073313

UniGene: Dm.2926