Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial

To produce recombinant EBV LMP1 protein, a well-established recombinant DNA technology is the key. A DNA template of LMP1 was constructed with N-terminal 6xHis tag using the technique. Once the template was made, the recombinant EBV LMP1 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 185-386aa of the EBV LMP1. The purity of this recombinant is 90% determined by SDS-PAGE.

LMP1 (BNLF1) is a protein coding gene that encodes Latent membrane protein 1. According to some studies, LMP1 may have the following features.
The Epstein-Barr virus transforming protein LMP1 engages the signaling proteins of the tumor necrosis factor receptor family. Epstein-Barr virus nuclear antigen 2 can transduce the latent membrane protein LMP1. Clonality and tumorigenicity of human epithelial cells expressing the Epstein-Barr virus-encoded membrane protein LMP1. LMP1 is known to be an oncogene in rodent fibroblasts and induces B lymphocyte activation and cell adhesion molecules in the Epstein-Barr virus-negative Burkitt's lymphoma cell line Louckes. Differences between LMP1 transcript and protein detection in NPC and highlight the role of EBV miRNAs in regulating LMP1 downstream signaling to promote cancer development. The subsequent loss of LMP1 expression may affect sites of persistent latent infection.