Recombinant Human 26S proteasome non-ATPase regulatory subunit 4 (PSMD4)

1. Preterm delivery is associated with low levels of anti-secretory factor in placenta. Inflammation, a potential trigger of preterm birth, is more pronounced in the preterm placenta and inversely related to the placental level of anti-secretory factor. PMID: 29265188
2. We therefore suggest that PSMD4 or b-catenin might be potential targets for suppressing tumor aggressiveness, and consequently, improving outcomes in patients whose tumors express cNrf2. PMID: 27033953
3. Binding (especially high-affinity binding) of non-ubiquitinated proteins to the Rpn10 proteasome subunit can both regulate the functioning of this proteasomal ubiquitin receptor (by competing with ubiquitinated substrates) and promote activation of other pathways for proteolytic degradation of proteins destined to the proteasome. PMID: 28988533
4. The platelet 26S proteasome exhibits different basal activities of its catalytic subunits and chymotrypsin-like activity is most prominently enhanced by calcium dependent signaling. Collagen stimulation enhances 26S proteasome chymotrypsin-like activity in platelets. PMID: 27768934
5. regulation of NY-ESO-1 processing by the ubiquitin receptors Rpn10 and Rpn13 as a well as by the standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites. PMID: 26903513
6. Not only AF1, but an entire proteasome complex, seems to be present in blood. PMID: 25897558
7. binds to death receptor-6, and induces monocyte cell line differentiation via NF-kB pathway PMID: 24829148
8. The VWA domain regulation of ubiquitin and Ubl binding to S5a is restricted to the 26S proteasome. PMID: 25318673
9. The degradation of TP53 and MDM2 by the proteasome can be selectively dependent on S5a in human cells. PMID: 24121268
10. To examine angiocidin expression in SMMC-7221 and HepG2 cells and the role of angiocidin in liver cancer cell growth. Angiocidin is highly expressed in liver cancer cells, and it may play a key role in tumor growth of liver cancers. PMID: 24250289
11. Authors demonstrate that human cytomegalovirus UL76 induces a novel nuclear aggresome, likely by subverting S5a of the ubiquitin-proteasome system. PMID: 23966401
12. One consequence of the interaction between E6/E6AP and S5a is enhanced ubiquitination of this proteasome subunit. PMID: 24074603
13. These studies suggest that diminished 26S activity in failing human hearts may be related ti impaired docking of the 19S to the 20S as a result of decreased Rpt subunit ATPase activity and alpha7 subunit phosphorylation. PMID: 23515276
14. identified the VWA domain of hRpn10 as a receptor for ubiquitin-like proteins within the 26S proteasome and elucidated how FAT10 mediates efficient proteolysis by the proteasome PMID: 22434192
15. Both higher PSMD4 expression levels and higher 1q21 copy numbers affected clinical outcome adversely. PMID: 21628408
16. results suggest that there is different substrate specificity between S5a and hRpn13 at the level of delivery and S5a may be the major docking site for ERAD substrates. PMID: 20417181
17. Overexpression of the S5a subunit of proteasome activator PA700 did not recover proteasome function in Huntington disease cells. S5a. PMID: 17327906
18. parkin Ubld uses differential surfaces to recruit UIM regions from the S5a proteasomal subunit compared with Eps15 involved in cell signaling. PMID: 19875440
19. S5a component of the 19S complex interacts with different ubiquitin-like (ubl) modules PMID: 11827521
20. HHr23a binds to this protein, which changes its own conformation. PMID: 14557549
21. structure of the ubiquitin-interacting motif of the proteasome subunit S5a bound to the ubiquitin-like domain of HR23B PMID: 14585839
22. Results report the structure of S5a (196-306) alone and complexed with two monoubiquitin molecules, and present a model for how S5a and other ubiquitin-binding proteins recognize polyubiquitin. PMID: 15826667
23. These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells. PMID: 16762342
24. UIM2 domain of S5a binds preferentially to hHR23a over polyubiquitin, and a model is provided for the ternary complex that represents one of the mechanisms used by the proteasome to capture ubiquitylated substrates. PMID: 17408689
25. results suggest that S5a is regulated during apoptosis at the transcriptional level and S5a upregulation by antiapoptotic signals can contribute to cell survival. PMID: 17459097
26. S5a-UIMs can be used as upstream inhibitors of the proteasome pathway. PMID: 17949686
27. In autoimmune disorders like MS, angiocidin activates T cells, macrophages, microglia & astrocytes to produce inflammatory cytokines and to stimulate antigen presentation. PMID: 18207252
28. angiocidin activates monocytes to secrete cytokines and differentiates them to a macrophage-like phenotype through at least two pathways mediated by MAPK and NF-kappaB, as well as PI3K PMID: 18632645
29. The presence of S5a in the reaction containing a substrate (luciferase), ubiquitination enzymes (an E2, UbcH5, and the U-box E3 ligase CHIP) and 26S proteasome significantly increased the rate of luciferase degradation. PMID: 19387488
30. Angiocidin's ability to elicit tumor cell death may be mediated in part by it's pro-inflammatory effects on immune cells in the tumor microenvironment. PMID: 19519434
31. The binding of S5a to K48-linked diubiquitin is defined at an atomic level resolution. PMID: 19683493
32. Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (also called subunit 5a) has two independent polyubiquitin binding sites whose sequences are highly conserved among higher eukaryotic orthologs. PMID: 9488668

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HGNC: 9561

OMIM: 601648

KEGG: hsa:5710

STRING: 9606.ENSP00000357879

UniGene: Hs.505059